Administration of nusinersen via paramedian approach for spinal muscular atrophy

ObjectiveTo assess the success rate, procedure time, and adverse events of intrathecal administration nusinersen via paramedian approach in adolescents adults with spinal muscular atrophy (SMA) associated scoliosis.MethodsSeven patients genetically confirmed SMA (age, 12–40 years) were included. Intrathecal was performed using fluoroscopy after determination largest interlaminal foramen among L2-L3, L3-L4, or L4-L5 by three-dimensional computed tomography. We measured times for preparation, positioning, puncture, total time stay. Adverse effects noted.ResultsIntrathecal successful all 38 opportunities. The median stay 44.0 min (interquartile range, 37.3–50.0 min). significantly longer type 1 than those 2, but not different according to severity scoliosis. included oxygen supplementation, headache, back pain. Sedation correlated supplementation headache.ConclusionsIntrathecal had advantages a high rate short fewer